In a study by Park et al. in 2011 the authors conclude that there are certain features evident on ultrasound that are highly specific for Morton's neuroma. This included what they described as the 'ginkgo leaf' sign. This effectively describes how the normal nerve suddenly expands to form the neuroma and how this is diagnostic.

The London Podiatry Centre considers all possible pathologies when a patient presents with a suspected neuroma, and will use other forms of technology such as CT, MRI and bone scan if required when the specific features are not entirely consistent with neuroma and could indicate a more serious condition such as a cancerous growth.