In a paper by MahaDevan et al. the authors reviewed the need for further intervention following steroid injection for Morton's neuroma. Interestingly, they found that large neuromas and neuromas that developed in younger patients were likely to require further treatment.

Certainly, The London Podiatry Centre has found that larger, more established neuromas can be difficult to treat. Our Centre has now developed specific techniques and refinements, particularly in relation to cryosurgery which allows for larger neuromas to be treated successfully. In the case of very large neuromas, open surgery may nevertheless be required in a small percentage of patients.